Infection characteristics and optimization of antimicrobial treatment among senile patients
Received:October 19, 2015  Revised:December 07, 2015
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DOI:10.11915/j.issn.1671-5403.2016.04.073
Key words:senile patients  infection characteristics  antimicrobial  treatment optimization
Author NameAffiliationE-mail
BAI Yan1, WANG Rui2* 1Drug Governance Center, 2Drug Clinical Research Center, Chinese PLA General Hospital, Beijing 100853, China 301@vip. sina.com 
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Abstract:
      Through reviewing literatures, we analyzed the infection characteristics in senile patients and features of antibacterial treatment optimization in them. On the basis of rational selection of antibiotics, we focused on and had a full understanding of the pathogenic bacteria, susceptibility to infections, clinical symptoms, condition changes, complications, clinical course, and efficacy and adverse reactions of antibiotic drugs in the elderly. In this article, based on the principles of clinical use of antibiotics and the characteristics of pharmacokinetics/pharmacodynamics (PK/PD) in these patients, we summarized the research progress in categories, dosage, treatment course and interphase, and combined use of antimicrobial drugs for the elderly with infective diseases. We aimed to fully grasp the infection characteristics and antibacterial treatment optimization so as to provide a theoretical basis for safer and more rational selection and use of antimicrobial agents for them.
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