Sodium channel can produce fast sodium current which is important for the occurrence and propagation of cardiac action potential, and also produce late sodium current (INaL) which contributes to action potential duration. Functional changes of sodium channel act as substrate for many cardiac diseases, and sodium channel may be remodeled in response to cardiac disease. Chronic heart failure (HF) is a common cardiac syndrome clinically. Sodium channel, especially concerning INaL and chronic HF, has become a hotspot in recent studies. We reviewed the relationship between the sodium channel and chronic HF in this article.