Clinical analysis on Uygur elderly patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension
  
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DOI:10.11915/j.issn.1671-5403.2015.12.208
Key words:pulmonary disease, chronic obstructive  pulmonary hypertension  aged
Author NameAffiliationE-mail
WU Hao1, JIAN Dai-Guo2, LIU Jin-Ming3*, Wureguli2, FAN Jiang-Peng2, Nuerziya2, MIAO Yu-Lin2, Abudurexiti2, YIN Xue-Lan2 1Department of Respiratory Diseases, the People’s Hospital of New Pudong District, Shanghai 201299, China
2Department of Respiratory Diseases, the People’s Hospital of Yarkant County, Kashgar 844700, China
3Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China 
jinmingliu2007@163.com 
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Abstract:
      Objective To analyze the clinical characteristics in the Uygur elderly patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension (PH). Methods Two hundred and eighteen Uygur elderly patients with stable COPD admitted in the People’s Hospital of Yarkant County from February 2014 to May 2015 were enrolled in this study. According to the results of echocardiography, they were divided into 3 groups, that is, the patients complicated with no PH (n=96), suspected PH (n=68) and identified PH (n=54). Age, sex, body mass index, medical history, lung function, blood gas analysis, and serum levels of hemoglobin (HGB) and pro-brain natriuretic peptide (pro-BNP) were compared between those with identified PH and with no PH. Results The complicated PH group had significantly longer history of chronic cough and phlegm (P<0.01), obviously higher incidence of diabetes (P<0.05), and remarkably higher serum levels of HGB and pro-BNP (both P<0.01) when compared with those with no PH. They also had significantly higher values in forced expiratory volume in one second percentage of predicted value (FEV1%pred), diffusing capacity percent predicted (DLCO% pred), and arterial partial pressure of oxygen (PaO2; P<0.01), but not in other indices of lung function(P>0.05). Conclusion Attention should be paid to the above abnormal features and standard treatment given correspondingly, which might delay the progression and improve the prognosis in the Uygur elderly patients of COPD combined with PH.
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