Objective To determine the impact of post-discharge statin withdrawal on the long-term prognosis in the elderly patients after acute myocardial infarction (AMI). Methods A retrospective follow-up study was carried out on the elderly patients who received percutaneous coronary intervention (PCI) treatment due to AMI in the Department of Cardiology of our hospital from January 2010 to December 2010. A total of 739 patients were recruited in this study, and divided into 2 groups on the basis of statin withdrawal history: statin withdrawal group (n＝178) and continued statin therapy group (n＝561). The incidences of long-term all-cause mortality and cardiac mortality were compared between the 2 groups. Results After 4 years’ follow-up, the statin withdrawal group had significantly higher all-cause mortality (21.4% vs 13.9%, HR＝1.62, 95%CI: 1.04?2.85, P＝0.008), and obvious higher cardiac mortality (14.5% vs 8.1%, HR＝1.98, 95%CI: 1.26?3.64, P＝0.002) when compared with the continued statin therapy group. Conclusion Post-charge statin withdrawal greatly increases the long-term mortality in the elderly AMI patients after PCI treatment. So, effective education and strict supervision about statin therapy are needed for these elderly patients to improve their long-term survival situation.