Objective To analyze the association of serum uric acid (SUA) with atrial fibrillation (AF) in the patients with chronic heart failure (CHF). Methods A total of 218 CHF patients admitted in our department from January 2010 to February 2014 were enrolled in this study. Their demographic data, medical history, blood biochemical parameters, ultrasonic echocardiogram and cervical vascular ultrasound results were collected and retrospectively analyzed. The patients were divided into 2 groups, that is, normal sinus rhythm group and AF group. Results Of 218 CHF patients, 49 patients (22.5%) had AF, and 169 patients were in normal sinus rhythm. SUA was significantly higher in the patients with AF than those with normal sinus rhythm (P＜0.05). AF patients were older than those with normal sinus rhythm [(64.32±9.87) vs (56.78±10.14) years, P＜0.05], had lower ejection fraction (EF, P＜0.05), higher values in echocardiographic parameters, such as left atrium diameter, left ventricular end-diastolic diameter, and left ventricular end systolic diameter, and obviously larger intimal medial thickness (P＜0.05). Multivariate logistic regression analysis showed that SUA was the independent risk factor for AF. Conclusion AF patients have significantly higher SUA levels, and poorer heart function.