Objective To explore the intervention to prevent multiple organ dysfunction syndrome in the elderly (MODSE) caused by pulmonary infection under the guide of multidisciplinary team work mode and find a basis for early prevention of the syndrome. Methods The multidisciplinary team prevention model was established to prevent MODSE caused by pulmonary infection. A total of 57 patients (over 65 years old) of high risk for MODSE due to pulmonary infection admitted in our ward from October 2010 to March 2014 were recruited in this study. Twenty-three of them underwent the intervention based on the multidisciplinary team prevention model, and assigned as multidisciplinary intervention group (MIG). Another 34 cases were treated by conventional intervention to prevent MODSE, and named as conventional intervention group (CIG). The incidence of MODSE was observed and compared between the 2 groups. Results In the MIG, there were 2 patients having MODSE, with an incidence of 8.70%. In the CIG, totally 11 patients (32.35%) suffered from MODSE. The incidence of MODSE was significantly lower in the MIG than CIG (Chi-square＝4.361, P＝0.037). Conclusion The multidisciplinary team prevention model can make full use of technical advantages of various disciplines, give optimal treatment to the high risk patients of MODSE caused by pulmonary infection, and thus reduce the occurrence of MODSE.