Objective To evaluate the effect of prolonged compression bandaging time on bleeding Atotol of complications after closing the femoral artery puncture point with the Angioseal artery occluders in the elderly. Methods Totally 728 elderly patients were selected for coronary angiography and interventional treatment, whose femoral artery puncture points were closed with Angioseal. These patients were randomly divided into the conventional treatment group (keeping postoperative straight leg lie for 6 hours, and then elastic pressure bandage was removed within 2h) and delayed bandaging group (keeping postoperative straight leg lie for 6 hours, and then elastic pressure bandage was not removed until 20?24h). The vascular complications and occurrent time were observed. Results There was significant difference in femoral artery puncture site complications between two groups. The incidence of puncture site bleeding and pseudoaneurysm from conventional treatment group was significantly higher than that from delayed bandaging one (7.42% vs 1.78%, P＝0.001). And bleeding complications were manifested as increased hemorrhagic complications after removement of compression bandage (conventional treatment group, 6.14%, and delayed bandaging group, 0.59%, P＝0.001). The formation incidence of pseudoaneurysm due to hemorrhage increased significantly in the conventional treatment group (1.53% vs 0.00%, P＝0.033). Although incidence of venous thrombosis due to local pressed hemostasis after bleeding increased (0.77% vs 0.30%, P＝0.628), there was no statistical difference. Conclusion Bleeding complication of femoral artery puncture site with Angioseal not only related with the puncture technique, but also with PCI postoperative anticoagulation and antiplatelet treatment. Extending compression time and reducing the early activities appropriately are very important means of reducing femoral artery puncture site bleeding complications.