Objective To investigate the role of comprehensive geriatric assessment (CGA) in comprehensive management for the elderly inpatients. Methods A standard CGA process was built and then employed to assess the elderly inpatients (over 65 years old) within 48 h after consecutively admitted in the Geriatric Ward of our hospital from September 2013 to September 2014. The effect of CGA was evaluated. Results Our standard CGA process was very convenient in clinical practice. There were 179 patients over 65 years were enrolled in this study, with an age of (72.5±8.1) years. CGA showed the following geriatrics syndrome: 62.0% with poor vision, 41.3% with sleep disorder, 40.8% with hearing loss, 34.6% with pain, 25.7% having falls, 23.5% having polypharmacy, 21.8% with constipation, 18.4% with mood disorder, 16.2% with incontinence, and 10.6% with cognitive impairment. There were 15 elderly patients (8.4%) who were admitted because of different complaints but finally discharged with the first diagnosis of geriatric syndrome. Conclusion Geriatric syndrome is very common in the elderly inpatients. Standard CGA can effectively screen those with geriatric syndrome, and helpful to the holistic management for them.