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| Correlation of lower extremities peripheral arterial disease and heart rate variability in elderly patients with type 2 diabetes mellitus |
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| DOI：10.11915/j.issn.1671-5403.2015.01.013 |
| Key words:diabetes mellitus, type 2 elderly peripheral artery disease, lower extremities heart rate variability |
| Author Name | Affiliation | E-mail | | YU Ling1, YANG Lei2, SONG Bin-Bin3, WANG Yong-Hui1, LI Lian-Xia1, GAO Shan1* | 1Department of Endocrinology, 3Department of Electrocardiography, Jingxi Branch, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100045, China
2Department of Neurology, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China | gaoshanmw@163.com |
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| Abstract: |
| Objective To investigate the correlation of lower extremities peripheral arterial disease (PAD) and heart rate variability (HRV) in the elderly patients (over 60 years) with type 2 diabetes mellitus (T2DM). Methods A total of 128 T2DM patients admitted to our hospital from June 2012 to July 2014 were included in this study. All subjects were divided into 2 groups according to having PAD or not [ankle brachial index (ABI)＜0.9 defined as PAD]. Their body mass index (BMI), blood pressure, serum lipids, peripheral neuropathy, urinary albumin excretion rate (UAER), ABI and HRV were measured and analyzed. Results In the 128 T2DM patients, there were 90 patients having no PDA and 38 having. Those with PAD had older age, longer diabetes duration, higher UAER, higher incidence of hypertension, and higher levels of HbA1c and triglycerides (TG) than the patients without PAD (P＜0.05). And they had lower HRV indices, including those in time domain, such as, the standard deviation of the R-R intervals (SDNN), mean of the standard deviation of the R-R intervals calculated in 5-min segments (SDNN-index) and the standard deviation of the averages of R-R intervals (SDANN), and those infrequency domain, high-frequency activity and low-frequency activity, for example. After adjustment for age, diabetes duration, UAER, levels of HbA1c and TG, and incidence of hypertension, HRV indices were negatively correlated with the severity of PAD. Conclusion In the cohort of the elderly T2DM patients, those with PAD have lower HRV indices than those without, suggesting a dysfunction of cardiovascular autonomic regulation. |
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