Efficiency of short-term continuous positive airway pressure therapy on obstructive sleep apnea hypopnea syndrome in senile and non-senile hypertension patients
  
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DOI:10.11915/j.issn.1671-5403.2015.01.011
Key words:sleep apnea, obstructive  hypertension  aged  continuous positive airway pressure
Author NameAffiliationE-mail
SHENG Hong-Yu, LI Nan-Fang*, OUYANG Wei-Jin, CHENG Qiu-Yan, TONG Ling, SUN Le, ZHANG Yan, RI-ZI-WAN-GU A-Bu-Dou, REN Ying-Li, ZU Fei-Ya Center of Diagnosis, Treatment and Research for Hypertension, Institute of Hypertension of Xinjiang Uygur Autonomous Region, Xinjiang People’s Hospital, Urumqi 830001, China Lnanfang2010@sina.com 
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Abstract:
      Objective To determine the effects of short-term continuous positive airway pressure (CPAP) therapy on obstructive sleep apnea hypopnea syndrome (OSAHS) in the senile and non-senile patients with coexisting hypertension. Methods A total of 100 inpatients suffering from OSAHS determined by polysomnography and hypertension admitted in our center from November 2012 to May 2013 were subjected in this study. They were divided into 2 groups according to their age over or under 60 years old, senile (n=12) and non-senile groups (n=88). Besides pre-existing antihypertensive medication, they were all given nocturnal CPAP therapy for 7 consecutive days (>6h/night). Their daily blood pressure, pre- and post-treatment blood pressure, decrease of the pressure and ratio of those achieving target blood pressure goal were measured and calculated, and the results were compared before and after treatment, and between the 2 groups for the efficiency of CPAP therapy. Results (1) In the 7th day after treatment, the morning systolic blood pressure [mSBP, (135.0±13.2) vs (140.6±15.0)mmHg, P<0.05, 1mmHg=0.133kPa], morning diastolic blood pressure [mDBP, (86.3±9.3) vs (93.3±11.5)mmHg, P<0.05], and morning mean blood pressure [(102.6±9.8) vs (109.1±11.7)mmHg, P<0.05] were significantly reduced when compared with the values before treatment in non-senile group, and the decrease of morning mean blood pressure at day 7 was greater than at day 1 after CPAP treatment [(9.2±11.7) vs (5.0±10.7)mmHg, P<0.05]. Whereas, no such difference was seen in the senile group (P>0.05). (2) The ratios of achieving target mSBP (80.7% vs 45.5%, P<0.05) and mDBP (80.7% vs 29.5%, P<0.05) were obviously higher in the non-senile group at day 7 than before the treatment. But there was no significant difference in the senile group (P>0.05). Conclusion Short-term CPAP therapy has better efficiency in non-senile than senile patients in the treatment of OSAHS with coexisting hypertension.
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