Objective To investigate the general condition and distribution of diseases in the death of the elderly patients, and analyze the change profile of serum high-sensitivity C-reactive protein(hs-CRP) and blood lipids in the patients died of coronary heart disease (CHD). Methods Clinical data of 97 died patients hospitalized in our department from 2009 to 2012 were collected and retrospectively analyzed. The patients were divided into 2 groups according to their causes of death being CHD or not. Their serum levels of hs-CRP and lipids were analyzed. Results The total mortality in our department at that period was 0.89%, with 1.12% for males, significantly higher than that for the females (0.69%, P＜0.05). The top 5 diseases of death cause were acute myocardial infarction, chronic congestion heart disease, pulmonary infection, sudden cardiac death and multiple valvular heart diseases. The serum level of total cholesterol (TC) was significantly higher in CHD-caused death group than in non-CHD one (P＜0.05). But there was no significant difference in the levels of hs-CRP, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) between the 2 groups (P＞0.05). Conclusion CHD is the major cause of death in the elderly people. TC level is obviously higher in the elderly died patients with CHD than those without the disease.