Objective To determine the guiding value of treadmill exercise test (TET) in the treatment of coronary intermediate lesions in proximal or middle left anterior descending artery (LAD). Methods Eight coronary heart disease patients with moderate coronary artery stenosis (diameter stenosis 30%?70%) in proximal or middle LAD and without obvious lesions in other coronary arteries admitted in our department from June 2012 to March 2014 were enrolled in this study. The patients were 6 males (75%) and 2 females (25%), at an age of (54.88±8.95) (ranging from 44 to 68) years. Coronary angiography was carried out on the patients within 3d after admission. TET would be done if the patient was found to have coronary intermediate lesions only in the proximal or middle LAD. The patient would be treated with intervention if the positive result was found in TET. Otherwise the patient would be treated with the optimal drug strategy. Results Among the patients with the diameter stenosis of 30%?70%, TET was positive in 2 patients who were treated with intervention. The 6 patients negative to TET were treated with the optimal drug strategy. During the follow-up of 1 month to 1 year, the 2 patients accepting intervention had no any discomfort such as chest pain, and the 6 patients with drug treatment also felt well and reported no serious adverse cardiac event. Conclusion TET plays an important role in guiding the treatment of coronary intermediate lesions in proximal and middle LAD.