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Anti-arrhythmic effect of omega-3 polyunsaturated fatty acids and its underlying mechanism: a review of research progress |
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DOI:10.3724/SP.J.1264.2014.00071 |
Key words:omega-3 polyunsaturated fatty acids anti-arrhythmic agent arrhythmia |
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Abstract: |
Much evidence shows that omega-3 polyunsaturated fatty acids (n-3PUFAs) protect the heart by reducing heart rate, increasing heart rate variability, decreasing atrial fibrillation, and preventing ventricular fibrillation arrhythmias and sudden cardiac death. However, some researches suggest that n-3PUFAs exert pro-arrhythmic action. The purpose of this review was to summarize the effects of n-3PUFAs on ion channels and anti-arrhythmic mechanism. Acute administration and long-term use of n-3PUFAs have quite different electrophysiological actions, indicating their anti- and pro-arrhythmic actions in different clinical settings. |
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