Anti-arrhythmic effect of omega-3 polyunsaturated fatty acids and its underlying mechanism: a review of research progress
  
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DOI:10.3724/SP.J.1264.2014.00071
Key words:omega-3 polyunsaturated fatty acids  anti-arrhythmic agent  arrhythmia
Author NameAffiliationE-mail
LAN Yun-Feng1, LI Yang2* 1Department of Healthcare, Hainan Branch of Chinese PLA General Hospital, Sanya 572000, China
2Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China 
liyangbsh@163.com 
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Abstract:
      Much evidence shows that omega-3 polyunsaturated fatty acids (n-3PUFAs) protect the heart by reducing heart rate, increasing heart rate variability, decreasing atrial fibrillation, and preventing ventricular fibrillation arrhythmias and sudden cardiac death. However, some researches suggest that n-3PUFAs exert pro-arrhythmic action. The purpose of this review was to summarize the effects of n-3PUFAs on ion channels and anti-arrhythmic mechanism. Acute administration and long-term use of n-3PUFAs have quite different electrophysiological actions, indicating their anti- and pro-arrhythmic actions in different clinical settings.
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