Arachidonic acid (AA) is one of the essential fatty acids for human beings, and its metabolites have strong biological activities and play important roles in regulating many physiological and pathological processes. AA is metabolized by three major pathways, including cyclooxygenases (COXs), lipoxygenases (LOXs) and cytochrome P450 (CYP). Recently, more and more evidences demonstrated that CYP pathway contributed to the pathogenesis of hypertension by regulating 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acid (EET), the downstream products of ω-hydroxylase and epoxygenase. The mechanisms of molecular biology and genetics of the pathway become a hot-spot in recent years. In this article, we reviewed the role of the CYP pathway in the hypertension.