As one of the most common gastrointestinal symptoms in the elderly, chronic constipation (CC) not only affects the seniors’ life quality, but also aggravates the risk of other diseases. Because of the complicated pathogenesis, CC in the elderly is difficult to cure. At present, comprehensive treatment is mainly based on the causes, classification and severity. Common treatments include adjusting life style, medication, psychological treatment, surgical treatment, biofeedback, etc. In this paper, the recent advances in the medication of CC in the elderly were reviewed, especially on the efficacy and safety of new drugs, such as 5-hydroxytryptamine (5-HT) receptor agonist, guanylate cyclase C agonist, chlorine ion channel activator, mu-opioid receptor antagonist, and so on.