Red cell distribution width and prognosis of cerebral infarction patients
  
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DOI:10.3724/SP.J.1264.2013.00206
Key words:red cell distribution width  cerebral infarction  prognosis  mortality
Author NameAffiliationE-mail
DING Yong1, WANG Fei2, HU Shan-You2* 1Community Health Service Center, Jiading Town, Jiading District, Shanghai 201800, China
2Emergency Department, Central Hospital of Jiading District, Shanghai 201800, China 
hsyheart@sina.com 
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Abstract:
      Objective To investigate the correlation of red cell distribution width (RDW) with the prognosis of cerebral infarction patients, and to explore the prognostic value of RDW. Methods A total of 159 cases of cerebral infarction diagnosed at admission in our department from May 2011 to May 2012 were enrolled in this study. They were divided into 2 groups according to their RDW median levels: low-level RDW group (n=80, RDW≤11.5%) and high-level RDW group (n=79, RDW>11.5%). The general clinical data, laboratory parameters, and mortality were compared between the 2 groups. And also, the patients were divided into survival group (n=144) and death group (n=15) based on their clinical outcomes. The RDW levels and mortality between the 2 groups were compared. The correlation between RDW and poor outcomes were analyzed by Spearman correlation test. Receiver operation characteristic (ROC) curve was used to determine the predictive value of RDW for hospital death. Results The mortality was significantly higher in the high-level RDW group than in the low-level RDW group (16.5% vs 2.5%, P=0.003). The RDW level was significantly higher in death group than in the survival group [(12.86±1.25)% vs (11.59±1.25)%, P=0.000]. Stepwise regression analysis indicated RDW had a positive correlation with poor outcome in the patients (standard partial regression coefficient=0.146, P=0.032). To predict hospital death, the area under ROC curve by RDW was 0.782 (95% CI 0.668?0.896). The best cut-off value determined by Yoden Index was 12.35 for RDW. The accuracy of prediction was 78.6%. Conclusion RDW level at admission in cerebral infarction patients is closely correlated with the short-term prognosis, and shows an important predictive value in the prognosis of the patients.
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