Objective To observe the application of comprehensive health education intervention in the patients after percutaneous coronary intervention (PCI) and evaluate the efficiency. Methods One hundred and six patients undergoing PCI in our institute from January 2012 to March 2012 were selected and divided into observation group and control group randomly (n=53). The patients in control group were given the routine treatment and traditional health education after surgery, while those from observation group were given the comprehensive health education intervention besides routine treatment. The efficiency of control of the risk factors of coronary heart diseases and the rate of rehospitalization were compared between the 2 groups at 6, 12 months after discharge from hospital. Results Blood pressure (BP), low density lipoprotein cholesterol (LDL-C) level and the rate of completing aerobic exercise were significantly better in observation group than in control group at 6 months after PCI(P＜0.05), while, there was no difference in body mass index (BMI), fasting plasma glucose, electrocardiogram (ECG) and rehospitalization rate between the 2 groups(P＞0.05). At 12 months after PCI, the BP value, LDL-C level, BMI, ECG, the rate of aerobic exercise, and rehospitalization rate were all well controlled in observation group than in control group, and the difference was statistically significant(P＜0.05). Conclusion Comprehensive health education intervention significantly controls the risk factors after PCI, and then decreases the rate of rehospitalization.