Shensong Yangxin capsule combined with amiodarone on premature ventricular contraction in aged patients with coronary heart diseases
  
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DOI:10.3724/SP.J.1264.2013.00167
Key words:Shensong Yangxin capsule  amiodarone  aged  coronary heart disease  premature ventricular contraction
Author NameAffiliationE-mail
YANG Jing*, CHEN Hong, DU Wan-Hong, LIU Xiao-Yang (Cadre’s Ward, Chinese PLA No.163 Hospital, Changsha 410003, China) 66823144@qq.com 
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Abstract:
      Objective To determine the clinical efficacy of Shensong Yangxin capsule (a traditional Chinese medicine) combined with amiodarone in treatment of premature ventricular contraction (PVC) in aged patients with coronary heart diseases. Methods A total of 68 patients with coronary heart diseases complicated with PVC hospitalized from January 2011 to December 2012 were recruited in this study. There were 62 males and 6 females, with age ranging from 67 to 80 (74.6±3.9) years. The patients were randomly divided into experimental group and control group, with 34 cases in each group. Both groups were treated with conventional therapy, and the control group was given amiodarone for 4 weeks, while, the experimental group received Shensong Yangxin capsule combined with amiodarone for 4 weeks. The clinical efficacy and adverse reactions in the 2 groups before and at 24h after treatment were observed by 24-hour dynamic electrocardiogram monitoring and signs and symptoms. Results After treatment, PVC in the experimental group was improved in 9 cases, effective in 21 cases, and invalid in 4 cases, with a total effective rate of 88.2%. While for the control group, PVC was improved in 5 cases, effective in 20 cases, and invalid in 9 cases, and the total effective rate was 73.5%. The total effective rate was significantly higher in the experimental group than in the control group (P<0.05). After treatment, the symptoms in the experimental group was improved in 8 cases, effective in 21 cases, and invalid in 5 cases, and the total effective rate was 85.3%. While, the symptoms of the control group was improved in 4 cases, effective in 22 cases, and invalid in 8 cases, and the total effective rate was 76.5%. There was significant difference in the total effective rate between the 2 groups (P<0.05). There were few adverse reactions found in the 2 groups, which was no significant difference between them (5.9% vs 8.8%, P>0.05). Conclusion Shensong Yangxin capsule combined with amiodarone is safe and more effective than amiodarone alone in the treatment of PVC in aged patients with coronary heart diseases.
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