Reperfusion therapy for acute myocardial infarction has the best opportunity to save patient’s life, reduce the early mortality and to improve patient’s life quality. The effective methods used to reintroduce blood flow to an ischemic region of the myocardium currently include intravenous thrombolysis, intracoronary thrombolysis, thrombectomy and intervention which directly catheterizes the infarct-related artery. Up to now, there is no report about reverse thrombolysis for acute coronary artery occlusion. In this paper, we reported a case with satisfactory result, who received reverse precise thrombolysis with urokinase along with stenting. Several critical issues need further investigation, including specific definition criteria of the target vessel thrombosis, standardized manipulation methods, as well as its long-term efficacy.