Acute drug-induced liver injury in 879 elderly Chinese: a meta-analysis
  
View Full Text  View/Add Comment  Download reader
DOI:10.3724/SP.J.1264.2013.00108
Key words:elderly  drug-induced liver injury  adverse drug reaction
Author NameAffiliationE-mail
ZHANG Ying, ZHANG Gan-Sheng, BAO Zhi-Jun, YU Xiao-Feng, ZHENG Song-Bai* (Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China) fdhuadong@163.com 
Hits: 1571
Download times: 1266
Abstract:
      Objective To investigate the clinical features and treatment strategy of acute drug-induced liver injury (DILI) in elderly Chinese patients. Methods Databases of CBM, VIP, Wanfang and CNKI were searched by retrieving from construction to 2011 with the key words “drug-induced liver injury or drug-induced liver disease, and elderly”. Data from retrieved literatures were summarized and analyzed by SPSS 14.0 software. Results There were 14 studies meeting the inclusion criteria, which included 879 elderly patients with acute DILI (583 males and 296 females). The main clinical manifestations were digestive symptoms (45.41%), jaundice (34.58%), fatigue (25.48%), and anorexia (21.84%), and so on. While, 308 patients (35.04%) were asymptomatic. Clinical classification indicated that hepatocellular type accounted for the largest proportion of acute DILI in the elderly (57.40%). The most common drugs causing acute DILI were antimicrobial agents (18.98%), Chinese traditional medicine (18.26%), cardiovascular drugs (17.90%) and antineoplastics (11.61%) in order. As for the prognosis, 692 of 774 cases (89.41%) were recorded being clinically cured or improved. Conclusion It is of great significance to diagnose and treat acute DILI early and properly, especially for the elderly patients so as to improve the prognosis and decrease mortality.
Close