Relationship of metabolic syndrome and MMP-9 activity with mild cognitive impairment in elderly patients
  
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DOI:10.3724/SP.J.1264.2013.00103
Key words:elderly  metabolic syndrome  mild cognitive impairment  matrix metalloproteinase 9
Author NameAffiliationE-mail
ZHAO Zhe, HUANG Gao-Zhong, YAN Hong, ZHONG Yuan* (Department of Geriatrics, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China) zhongyuan1946@sohu.com 
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Abstract:
      Objective To determine the correlations of metabolic syndrome (MS) with mild cognitive impairment (MCI) in the elderly, and investigate the role of matrix metalloproteinase 9 (MMP-9) activity in the process. Methods A total of 135 MS patients [MS group, with an age ranging from 65 to 76 (67.8±6.1) years] and 75 healthy control subjects [Control group, with an age ranging from 65 to 75 (66.3±5.9) years] admitted in our department from March 2009 to June 2012 were enrolled in this study. Mini-mental status examination (MMSE) was applied to evaluate their cognitive function. The plasma levels of MMP-9 and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured to estimate MMP-9 activity by calculating the ratio of MMP-9 to TIMP-1. Results MCI was more common in MS group than in control group (22.2% vs 9.33%, P<0.05). The scores of MMSE were significantly lower in MS group than in control group [(26.12±1.15) vs (29.37±0.58), P<0.05]. MS group had significant higher MMP-9 activity than the control group [(0.81±0.35) vs (0.59±0.27), P<0.05]. In MS group, the MMP-9 activity was negatively correlated with MMSE score (r=-0.519, P<0.05). A high level of education was a protective factor of MCI (OR=0.615, P=0.023), while MS, diabetes and MMP-9 activity were independent risk factors of MCI (OR1=6.981, P1=0.011; OR2=6.250, P2=0.017; OR3=3.262, P3=0.031). Conclusion MS is an independent risk factor of MCI. In MS patients, MMP-9 activity is positively correlated with the severity of MCI.
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