Correlationship of renal function parameters with serum levels of leptin and adiponectin in patients with hyperlipidemia
  
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DOI:10.3724/SP.J.1264.2012.00236
Key words:hyperlipidemia  urea nitrogen  serum creatinine  leptin  adiponectin
Author NameAffiliationE-mail
LIU Peng1*, LI Jiao1, XU Hui2, YUE Zhigang2, GUO Jihong3 China Meitan General Hospital: 1Department of Cardiology, 2Clinical Laboratory, Beijing 100028, China
3Department of Cardiology, People¢s Hospital, Peking University, Beijing 100044, China 
liupeng1037@sohu.com 
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Abstract:
      Objective To evaluate the correlation of renal function parameters with serum levels of leptin and adiponectin in patients with hyperlipidemia. Methods Totally 540 cases were enrolled, including 336 patients with hyperlipidemia and 204 cases as normal controls. All patients with hyperlipidemia were divided into 4 subgroups according to their clinical types, including hypercholesterolemia group, hypertriglyceridemia group, mixed hyperlipidemia group, and low high-density lipoproteinemia cholesterol (HDL-C) group. Blood urea nitrogen (BUN), serum creatinine (SCr) concentrations, serum levels of leptin and adiponectin were measured in each group. Results Compared with normal control group, BUN levels in all the groups of hyperlipidemia were higher to various extent, but only the mixed hyperlipidemia group had statistical significance (P<0.05). BUN levels in the mixed hyperlipidemia group were significantly higher than those in hypercholesterolemia group and hypertriglyceridemia group (P<0.05). SCr concentrations in hypertriglyceridemia group and low HDL-C group were significantly higher than those in normal controls, as well as than those in hypercholesterolemia group and the mixed hyperlipidemia group (P<0.05). Adiponectin level in low HDL-C group was higher than that in normal control group (P<0.05). Leptin concentration in hypertriglyceridemia group was lower than low HDL-C group (P<0.05). Adiponectin level in hypercholesterolemia group was also lower than that in low HDL-C group (P<0.05). Conclusion Elevated BUN and SCr levels are observed in patients with hyperlipidemia. Serum levels of leptin and adiponectin may serve as diagnostic and prognostic indicators of renal function injury in patients with hyperlipidemia.
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