Objective To study the psychological intervention on the elderly cases of coronary heart disease with depression and anxiety. Methods Totally 102 cases of coronary heart disease with depression and anxiety were randomly divided into two groups: the simple drug treatment group (the control group) and psychological intervention with drug treatment group (psychological intervention group). Both the two groups were scored by Self-Rating Anxiety Scale(SAS), Self-Rating Depression Scale(SDS) and Seattle Angina Questionnaire(SAQ) before treatment and four weeks later. Clinical efficacy was evaluated when the patients were discharged. Results There were no significant differences in SAS, SDS and SAQ scores between the two groups before treatment. The SAS, SDS and SAQ scores of psychological intervention group were significantly improved compared with those of the control group when re-evaluation was conducted after four weeks (P＜0.05). Conclusion Psychological intervention has good therapeutic effect on the elderly patients of coronary heart disease with depression and anxiety.