Systemic inflammatory response syndrome: clinical study of 54 very old patients
  
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DOI:10.3724/SP.J.1264.2012.00204
Key words:elderly, over 80 years  systemic inflammatory response syndrome  multiple organ failure  immunomodulator
Author NameAffiliationE-mail
WU Ning, KONG Qingjun, QI Yuqin, et al First Department of Geriatrics, Nanjing General Hospital, Research Center for Geriatrics, Nanjing Military Command, Nanjing 210002, China wanwhnj@sina.com 
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Abstract:
      Objective To investigate the clinical characteristics of very old patients with systemic inflammatory response syndrome (SIRS) and the relationship between treatment options and prognosis. Methods Fifty-four very old patients with SIRS were randomly divided into two groups. The control group included 28 patients, receiving only a standard anti-infection treatment and traditional respiratory support, and the treatment group included 26 patients, receiving a stepwise respiratory, nutrition support and immunomodulator besides a standard anti-infection treatment. Their differences in morbidity and fatality rate of multiple organ dysfunctions syndrome (MODS) were compared and analyzed. Results The morbidity and fatality rate of MODS in the treatment group were 38.5% and 7.7% respectively, and were significantly lower than those in the control group (57.1% and 28.6% respectively, P<0.05). Conclusion In the elderly, progressive SIRS will lead to the occurrence of MODS. MODS is a major cause of death in the elderly patients with severe infection. Stepwise respiratory plus nutrition support and immunomodulator can significantly improve the cure rate of SIRS.
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