Different doses of atorvastatin calcium for elderly patients with unstable angina pectoris and non-revascularization
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Key words:unstable angina pectoris  non-revascularization  atorvastatin calcium
Author NameAffiliationE-mail
MA Jianxin, HE Yongfeng, SONG Chengyun, et al 1Department of Cardiology, Chinese PLA 305th Hospital, Beijing 100017, China
2Department of Medical Affairs, CCCPC Literature Research Office, Beijing 100017, China
3Department of Cardiology, First Hospital, Peking University, Beijing 100034, China 
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      Objective To observe the safety and effectiveness of different doses of atorvastatin calcium for patients with unstable angina pectoris (UA) and non-revascularization. Methods Thirty-eight elderly patients with UA and non-revascularization were randomly divided into 2 groups. One group received atorvastatin calcium 20mg daily, the other group 40mg instead. Total cholesterol(TC), triglyceride (TG), low-density lipoprotein cholesterol(LDL-C) and lipid profiles were measured at 1 and 3 months, as well as Holter examination results, main adverse cardiac events(MACE) and adverse drug reaction. Results After treatment, TC, TG and LDL-C in two groups were significantly reduced (P<0.05). Compared with 20mg group, both the degree and the duration of ischemic ST segment depression were significantly decreased (P<0.05), and the incidence of MACE, including nonfatal myocardial infarction, recurrent angina pectoris and rehospitalization due to symptomatic myocardial ischemia, was significantly lower in 40mg group (P<0.05). There was no significant difference in the incidence of adverse drug reaction between the two groups (P>0.05). Conclusion For elderly patients with UA and non-revascularization, atorvastatin calcium both the dose 20mg/d and 40mg/d can regulate effectively the blood lipid profiles. Atorvastatin calcium at the dose of 40mg/d has more significant effectiveness.