Objective To investigate the drug resistance of pan-drug resistant Acinetobacter baumannii(PDR-AB) to common disinfectants. Methods K-B paper method was used in routine drug susceptibility test. Paper method and broth cultivation were used in disinfectants susceptibility test. Results The PDR-AB was sensitive to 0.5% povidone iodine (PVP-I) disinfectant,0.1% chlorhexidine acetate solution, 2000ppm trichlorosocynuric acid (freshly prepared), and 2% glutaraldehyde(soak), but resistant to 75% ethanol, 0.1% chlorine oxide, 0.1% PVP-I, and 2000ppm trichlorosocynuric acid(prepared 30 minutes later). Conclusion The 0.5% PVP-I disinfectant, 0.1% chlorhexidine acetate solution, 2000ppm trichlorosocynuric acid (freshly prepared), and 2% glutaraldehyde(soak) show excellent efficacy in killing clinically isolated PDR-AB, but low concentration of PVP-I and chlorine-containing disinfectants and 75% ethanol show poor efficacy.