Objective To explore the safety and efficacy of hemodialysis treatment during percutaneous interventional(PCI) therapy for coronary artery disease patients complicated by chronic renal insufficiency. Methods Patients with coronary heart disease combined with chronic renal dysfunction were selected. For all patients, hydration and alkalization were performed by giving continuous oral administration of sodium bicarbonate tablets 1g(three times daily, for 3 days) and intravenous infusion of sodium chloride 1000～1500ml within 3-12 hours before PCI operation, 3～10ml/(kg?h). After PCI treatment, indwelling of femoral artery puncture sheath tube was kept and patients were transferred to the dialysis room immediately and underwent 4 hours of dialysis treatment to protect renal function. Changes in renal function were analyzed. Results All patients underwent PCI treatment successfully. No obvious complication or stent thrombosis was detected within one month after PCI. Among 58 cases, 56 showed no significant increase in plasma creatinine levels compared with those before operation; one patient showed increased plasma creatinine level; one patient required permanent dialysis. Conclusion Interventional therapy is not an absolute contraindication for patients with coronary heart disease combined with renal dysfunction. Interventional treatment can be performed safely when the renal function of patients are protected adequately.