ObjectiveTo demonstrate the roles of androgen in the heart injury of high-salt fed male rats,and to explore the interventional effect of angiotensin Ⅱ receptor type 1(AT1R) antagonist. MethodsForty Wistar rats were randomly assigned to sham-operation (Sham) group,castration (Cas) group,testosterone (Tes) supplement group,and candesartan (Cand) intervention group,with 10 in each group. All animals fed high-salt diet (8% NaCl) for 8 weeks. Animals in Sham group received sham operation,while those in Cas,Tes and Cand groups received surgical castration. Intramuscular injection of testosterone 4mg/(kg·2week) was performed in Tes and Cand groups,and intragastric administration of candesartan 3mg/(kg·d) in Cand group. The blood pressure of tail artery was measured at baseline,4 and 8 weeks after experiment respectively. At 8 weeks after experiment,the left ventricular weight (LVW),and left ventricle/body mass index (LVI) were determined; pathological changes in myocardium were observed; and serum testosterone concentration was measured by RIA. ResultsAfter 8 weeks of high-salt diet feeding,compared with the basic level,the blood pressure increased significantly in Sham and Tes groups (P<0.01); compared with Sham group,it decreased significantly in Cand or Cas group (P<0.01). LVW and LVI in Cand or Cas group decreased significantly compared with Sham group(P<0.01). Compared with Sham group,the morphological features of myocardium in Can or Cas group remained and intact and clear. ConclusionAndrogen plays a role in high-salt-induced left ventricular hypertrophy and blood pressure elevation. AT1R antagonist can exert some interventional effects.?更多