ObjectiveTo analyze the clinical characteristics of chronic obstructive pulmonary diseases (COPD) patients with acute exacerbation and liver function impairment and the influence of the liver-protective therapy on the prognosis of the patients. MethodsAll selected patients received basic therapy,and were divided into 3 groups. In group A,56 COPD patients with liver function impairment received liver-protective therapy. In group B,42 COPD patients with liver function impairment received no liver-protective therapy. In group C,68 COPD patients without liver function impairment received no liver-protective therapy. The clinical symptoms,the laboratory test results,hospitalization duration,hospitalization cost,and the clinical outcome were compared among three groups. ResultsCompared with group C,the patients in group A and B displayed a worse clinical outcome,more severe clinical symptoms,higher hospitalization cost,and longer hospitalization duration. The hospitalization cost was higher in group A than in group B 〔(9 534±326) vs (7 864±265) RMB yuan)〕,while hospitalization duration 〔(25±6) vs (25±6)d〕,recovery of liver function,mortality (17.3% vs 16.8%) had no significant difference between group A and B. ConclusionLiver function impairment in COPD patient with acute exacerbation extends hospitalization duration,increases hospitalization cost,and raises the patients’ mortality. However,liver-protective therapy exerts no effect on the prognosis of the patients.