Objective To discuss whether the B-type natriuretic peptide (BNP) level in acute phase of acute myocardial infarction (AMI) was affected by emergency percutaneous coronary intervention(PCI) therapy,and whether it was predictive of the long-term mortality of AMI patients. Methods Two hundred and thirty consecutive AMI patients in CCU were enrolled. The BNP level was compared between emergency PCI group and non-PCI group. The patients were followed up for a period of (38.1±8.5) months averagely,with follow-up rate of 86.1%. The cardiogenic death cases were recorded. Survival rate of non-cardiogenic death cases was analyzed with Kaplan-Meier curve. Survival rate of patients with different levels of BNP was compared with Log Rank method. Results LnBNP was significantly lower in emergency PCI group than in non-PCI group(5.0±1.2 vs 5.8±1.3,P<0.001). LnBNP after 3-year follow-up visit was significantly lower in survival group than in cardiogenic death group(5.3±1.3 vs 6.6±1.1,P<0.001). The survival rate was significantly higher in emergency PCI group than in non-PCI group(93.4% vs 77.5%,P<0.001). BNP of 316.5ng/L was determined as the cut-off point according to ROC curve. The Kaplan-Meier curves demonstrated that the survival curves of the two groups separated apparently. Log Rank analysis displayed that the survival rate was significantly higher in low BNP level group than in high BNP level group (95.1% vs 66.4%,P<0.001). Conclusion Emergency PCI could reduce BNP level in acute phase of AMI. BNP is an excellent biomarker for long-term outcome of AMI and is strongly correlated with the long-term mortality of AMI.?更多