Objective To investigate the effects of percutaneous coronary intervention(PCI) on the treatment and prognosis of heart failure derived from ischemic cardiomyopathy in aged patients. Methods The subjects were divided into 2 groups: treatment group(n=55)and control group(n=56).The patients in the treatment group received PCI as well as conservative medication,while the patients in the control group underwent conservative medication only. The short-term therapeutic effects and long-term prognosis were compared between the two groups. Results In PCI treatment group, the patients had a significant amelioration of physical signs, significant elevation of LVEF, significant reduction of rehospitalization frequency in 1-and 2-year follow-up visit,and cardiac death in 4-and 8-year follow-up visit.It was significantly different compared to the control group(P<0.05). Conclusion The application of PCI in treating heart failure resulting from ischemic cardiomyopathy in aged patients is feasible and fruitful if the patients can stand the procedure.Especially,the long-term prognosis is statisfactory.