The advent of interventional technology has generated new approaches to clinical diagnosis and treatment, and its develop-ment has also been accompanied by continuous improvements in procedure safety. Regardless of whether in peripheral vascular intervention or in cardiovascular and cerebrovascular intervention, intravascular administration of contrast agents is mostly required, and the use of contrast agents has the risk of causing acute kidney injury, leading to major complications, prolonged hospital stay, and poor prognosis. This article reviews the clinical problem of acute contrast-induced kidney injury in the respects of its pathophysiology, diagnosis, predictive factors, and clinical management, with a view to providing references in clinical decisions.